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INTESTINAL Publication-derived
Intestinal Organoids (2014)
No SOP yet
Source Middendorp et al. · University Medical Centre Utrecht and Hubrecht Institute, Netherlands
Authors: Middendorp S, Schneeberger K, Wiber S, Nos KM, van de Wetering M, Clevers H, Nieuwenhuis EES Duration: 28 days Cell source: Primary (Human Duodenal, Jejunal, Ileal, and Colonic Biopsies)
Abstract
Established organoids from four intestinal regions demonstrating stable retention of regional identity through HOX gene expression and site-specific drug metabolism patterns. Duodenal organoids expressed highest CYP3A4 levels, supporting regional drug metabolism profiling for oral drug development.
Cell source
Primary (Human Duodenal, Jejunal, Ileal, and Colonic Biopsies)
Application
Regional Drug Absorption
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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