INTESTINAL Publication-derived

Human Duodenal Organoids for Celiac Disease Modeling

Source Senger et al. · Massachusetts General Hospital, Boston, USA · 10.1038/mi.2015.36

👤 Senger S, Sapone A, Fiorentino MR, Mazzarella G, Larazattera M, Fasano A ⏱ 10080 min 🧫 Primary (Human Duodenal Biopsies from Celiac and Control Patients)

Abstract

Established duodenal organoids from celiac disease patients that recapitulate gliadin-induced barrier dysfunction through zonulin release and tight junction disassembly. Celiac-derived organoids showed enhanced innate immune responses compared to controls, providing a platform for celiac drug development.

Cell source

Primary (Human Duodenal Biopsies from Celiac and Control Patients)

Application

Celiac Disease Modeling

Full SOP

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Attribution

This SOP was authored by Organthis based on the published method in Senger et al.. The originating laboratory holds no rights in this SOP and has not endorsed it unless marked Verified.

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