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INTESTINAL Publication-derived
Intestinal Organoids (2016)
No SOP yet
Source Dekkers et al. · University Medical Centre Utrecht and Erasmus MC, Netherlands
Authors: Dekkers JF, Berkers G, Kruisselbrink E, Vonk A, de Jonge HR, Janssens HM, Bronsveld I, van de Graaf EA, Nieuwenhuis EES, Houwen RHJ, Vleggaar FP, Escher JC, de Rijke YB, Majoor CJ, Heijerman HGM, de Winter-de Groot KM, Clevers H, van der Ent CK, Beekman JM Duration: 14 days Cell source: Primary (Human Rectal Biopsies from CF Patients with Rare CFTR Genotypes)
Abstract
Demonstrated that organoid forskolin-induced swelling predicts clinical ivacaftor response for rare CFTR mutations lacking clinical trial data. This paradigm enables drug access through compassionate use programs and has been accepted for reimbursement decisions in the Netherlands.
Cell source
Primary (Human Rectal Biopsies from CF Patients with Rare CFTR Genotypes)
Application
Rare Mutation Drug Access
No step-by-step SOP yet
OrganMatch™ lists this published method, but there is no step-by-step SOP for it yet.
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