LIVER Publication-derived

Vascularized iPSC Liver Bud (Takebe/Taniguchi)

Source Takebe et al. · Yokohama City University / Cincinnati Children's Hospital

👤 Takebe T, Sekine K, Enomura M, Koike H, Kimura M, Ogaeri T, Zhang RR, Ueno Y, Zheng YW, Koike N, Taniguchi H ⏱ 16800 min 🧫 Human iPSC + HUVEC + Mesenchymal Stem Cells

Abstract

Takebe und Taniguchi demonstrierten die Selbstorganisation von iPSC-Hepatendoderm, HUVECs und MSCs zu dreidimensionalen Leberknospen auf Matrigel. Nach Transplantation in immundefiziente Mäuse wurden humane Gefäßnetzwerke durch Hostiengefäße perfundiert; die Leberknospen reiften zu funktionalem Lebergewebe. Bahnbrechendes Konzept für biologisches Leber-Engineering — eines der meistzitierten Organoid-Papers überhaupt.

Cell source

Human iPSC + HUVEC + Mesenchymal Stem Cells

Application

Regenerative Medicine

Full SOP

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Attribution

This SOP was authored by Organthis based on the published method in Takebe et al.. The originating laboratory holds no rights in this SOP and has not endorsed it unless marked Verified.

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