LIVER Publication-derived

NASH Liver Organoids from Irreversibly Damaged Tissue (McCarron

Source McCarron et al. · Weill Cornell Medicine, New York / Columbia University · 10.1002/hep.31857

👤 McCarron S, Bathon B, Conlon DM, Abbey D, Remaley AT, Bhatt DL, Cosgrove BD, Gordts PLSM, Bhatt DL ⏱ 12000 min 🧫 NASH Patient Liver Biopsy (explantierte Lebern, Transplantation)

Abstract

McCarron et al. (Weill Cornell) demonstrierten, dass Leberorganoids aus irreversibel geschädigtem NASH-Gewebe (explantierte Transplantationsleben) erfolgreich etabliert werden können. Diese Organoids bewahrten NASH-Genexpressionsprofile und reagierten auf Drug Screening (Obeticholic Acid, Elafibranor). Eröffnet die Möglichkeit, personalisierte NASH-Organoids auch aus schwersten Erkrankungsstadien zu generieren.

Cell source

NASH Patient Liver Biopsy (explantierte Lebern, Transplantation)

Application

End-stage NASH Research

Full SOP

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Attribution

This SOP was authored by Organthis based on the published method in McCarron et al.. The originating laboratory holds no rights in this SOP and has not endorsed it unless marked Verified.

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