LIVER Publication-derived

Hep-Org from Fetal Tissue

Source Hu et al. · Hubrecht Institute, Utrecht

👤 Hu H, Gehart H, Artegiani B, Clevers H ⏱ 10080 min 🧫 Human Fetal Liver Tissue (Hepatoblasts)

Abstract

Hu und Clevers (Hubrecht, Cell 2018) beschrieben neben adulten Hep-Orgs auch fetale Leberorganoids aus humanen Hepatoblasten. Fötale Organoids zeigten Bipotenz (Hepatozyten + Cholangiocyten), AFP/ALB-Koexpression und eine Lgr5+ Subpopulation. CYP3A4-Aktivität war geringer als in adulten Hep-Orgs — wichtig für entwicklungsbiologische Studien und Modellierung kongenitaler Lebererkrankungen.

Cell source

Human Fetal Liver Tissue (Hepatoblasts)

Application

Developmental Biology

Full SOP

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Attribution

This SOP was authored by Organthis based on the published method in Hu et al.. The originating laboratory holds no rights in this SOP and has not endorsed it unless marked Verified.

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